One of the biggest challenges in skincare is getting key ingredients to go deeper into skin so their impact is more profound. Due to research and development, Physician-Grade Cosmeceuticals are far more likely to do this than OTC products. Most Physician lines are created and formulated by physicians, scientists and skin professionals who have researched ingredients for years and put them into action in their own practices. They are custom formulated to have ingredients that actually reach their intended targets, such as the basal layer, to encourage actual change. Most drugstore and department store lines simply sit at the surface of your skin and provide hydration and absolutely no change in the quality, appearance, or health of your skin.